Alessandro Pecci Selected Research

MYH9-Related Disorders

2/2019	MYH9-Related Thrombocytopenia: Four Novel Variants Affecting the Tail Domain of the Non-Muscle Myosin Heavy Chain IIA Associated with a Mild Clinical Evolution of the Disorder.
1/2019	MYH9-related disease mutations cause abnormal red blood cell morphology through increased myosin-actin binding at the membrane.
1/2016	Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease.
6/2014	Cochlear implantation is safe and effective in patients with MYH9-related disease.
2/2014	MYH9-related disease: a novel prognostic model to predict the clinical evolution of the disease based on genotype-phenotype correlations.
1/2013	MYH9-related disease: five novel mutations expanding the spectrum of causative mutations and confirming genotype/phenotype correlations.
1/2012	Alteration of liver enzymes is a feature of the MYH9-related disease syndrome.
10/2011	Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells.
2/2011	The irreversibility of platelet aggregation is regulated by myosin IIA, but is not compromised in MYH9-related disease.
9/2010	A G to C transversion at the last nucleotide of exon 25 of the MYH9 gene results in a missense mutation rather than in a splicing defect.

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Alessandro Pecci Research Topics

Disease

28	Thrombocytopenia (Thrombopenia) 01/2022 - 03/2006
20	MYH9-Related Disorders 02/2019 - 04/2002
11	Hemorrhage 01/2022 - 03/2011
5	Neoplasms (Cancer) 09/2017 - 02/2013
4	Cataract (Cataracts) 02/2019 - 06/2004
3	Deafness (Deaf Mutism) 02/2019 - 06/2004
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 12/2016 - 02/2013
3	Bernard-Soulier Syndrome (Giant Platelet Syndrome) 09/2014 - 03/2011
3	Primary Myelofibrosis (Myelosclerosis) 05/2007 - 02/2004
3	Glomerulonephritis 05/2006 - 01/2003
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2016 - 07/2002
2	Sensorineural Hearing Loss 01/2016 - 05/2006
2	Inborn Genetic Diseases (Disease, Hereditary) 02/2013 - 08/2012
2	Cytopenia 02/2013 - 02/2004
2	Renal Insufficiency (Renal Failure) 06/2004 - 01/2003
1	Lemierre Syndrome 02/2019
1	Abscess 02/2019
1	Sepsis (Septicemia) 02/2019
1	Congenital amegakaryocytic thrombocytopenia 01/2018
1	Infections 01/2018
1	Bone Marrow Failure Disorders 01/2018
1	Glioblastoma (Glioblastoma Multiforme) 09/2017
1	Thrombocytopenia chromosome breakage 01/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017
1	Aplastic Anemia (Anemia, Hypoplastic) 12/2016
1	Hearing Loss (Hearing Impairment) 01/2016
1	Inflammation (Inflammations) 08/2015
1	Crohn Disease (Crohn's Disease) 07/2015
1	Gastritis 02/2013
1	Neutropenia 02/2013
1	Type 2 von Willebrand Disease 01/2009
1	Thrombocytosis (Thrombocythemia) 12/2007
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 08/2005
1	Congenital Abnormalities (Deformity) 06/2004
1	Splenomegaly 02/2004
1	Dyserythropoietic Anemia with Thrombocytopenia 01/2004
1	Thalassemia 01/2004
1	Thrombocytopenia 1 01/2004
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2003

Drug/Important Bio-Agent (IBA)

14	Nonmuscle Myosin Type IIAIBA 01/2019 - 04/2002
8	Thrombopoietin (c-mpl Ligand)IBA 01/2020 - 12/2007
8	Myosin Heavy Chains (Myosin Heavy Chain)IBA 02/2019 - 06/2004
5	eltrombopag FDA Link 01/2020 - 12/2010
4	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2013
3	5' Untranslated Regions (5' UTR)IBA 01/2017 - 01/2011
3	von Willebrand FactorIBA 09/2014 - 01/2009
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 10/2012
2	Pharmaceutical PreparationsIBA 01/2021 - 12/2016
2	Hemostatics (Antihemorrhagics)IBA 01/2021 - 01/2017
2	EnzymesIBA 02/2019 - 01/2012
2	Myosins (Myosin)IBA 01/2019 - 08/2012
2	NucleotidesIBA 01/2017 - 05/2015
2	Peptides (Polypeptides)IBA 12/2016 - 07/2011
2	UbiquitinIBA 06/2015 - 02/2013
2	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2015 - 02/2013
2	Protein Isoforms (Isoforms)IBA 02/2014 - 06/2004
2	Thrombopoietin ReceptorsIBA 07/2013 - 12/2010
2	Collagen Type I (Type I Collagen)IBA 10/2011 - 07/2009
1	Anti-Bacterial Agents (Antibiotics)IBA 02/2019
1	AnticoagulantsIBA 02/2019
1	CollagenIBA 01/2019
1	convulxinIBA 01/2019
1	romiplostim FDA Link 01/2018
1	4,5,6,7- tetrahydroisoxazolo(4,5- c)pyridin- 3- ol (THPO)IBA 01/2018
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2017
1	Fibrinogen (Factor I)FDA Link 11/2016
1	Amino Acids FDA Link 01/2016
1	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 07/2015
1	AntigensIBA 07/2015
1	ActininIBA 01/2015
1	Cytochromes c (Cytochrome c)IBA 02/2014
1	Inosine Triphosphate (ITP)IBA 07/2013
1	DiamondIBA 02/2013
1	Dronabinol (THC)FDA LinkGeneric 10/2012
1	von Willebrand factor receptor (VWF receptor)IBA 12/2011
1	Platelet Membrane GlycoproteinsIBA 12/2011
1	Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)IBA 01/2009
1	Complementary DNA (cDNA)IBA 12/2008
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 12/2007
1	Interleukin-6 (Interleukin 6)IBA 12/2007
1	Hormones (Hormone)IBA 12/2007
1	Chemokine ReceptorsIBA 05/2007
1	Integrin alpha2IBA 03/2006
1	Glycoproteins (Glycoprotein)IBA 03/2006
1	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA 08/2005
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 08/2005
1	Myosin Type IIIBA 06/2004
1	Thalidomide (Thalomid)FDA Link 02/2004
1	DNA (Deoxyribonucleic Acid)IBA 01/2004
1	NPHS2 proteinIBA 01/2003

Therapy/Procedure

4	Therapeutics 01/2021 - 03/2013
3	Platelet Transfusion (Blood Platelet Transfusions) 01/2020 - 12/2010
1	Debridement 02/2019
1	Ligation 02/2019
1	Operative Surgical Procedures 02/2019
1	Hematopoietic Stem Cell Transplantation 01/2018
1	Hysterectomy 08/2014
1	Blood Transfusion (Blood Transfusions) 08/2014
1	Cochlear Implantation 06/2014
1	Transjugular Intrahepatic Portasystemic Shunt 07/2009